Team | Player | PTS |
| Jonathan Taylor RB | IND | Lady Cougars | 16 |
| Christian McCaffrey RB | SF | Juggernauts | 15.8 |
| Kyren Williams RB | LAR | Big Dog Sports | 15.6 |
| Josh Jacobs RB | GB | The Dominators | 15 |
| Saquon Barkley RB | PHI | Not Dead Yet | 14.8 |
| Bijan Robinson RB | ATL | The Dominators | 14 |
| De’Von Achane RB | MIA | Da Yoopers | 13.8 |
| James Cook RB | BUF | Mad Mudders | 13.8 |
| Ashton Jeanty RB | LV | Juggernauts | 13 |
| Javonte Williams RB | DAL | Not Dead Yet | 12.8 |
| Jacory Croskey-Merritt RB | WAS | W ( 10/8) | 11.8 |
| Jahmyr Gibbs RB | DET | Sack Attack | 11.6 |
| Derrick Henry RB | BAL | Mad Mudders | 10.6 |
| Travis Etienne RB | JAC | Da Yoopers | 10.6 |
| Breece Hall RB | NYJ | Team Up Honor | 10.4 |
| Quinshon Judkins RB | CLE | Sack Attack | 10.4 |
| Kenneth Walker III RB | SEA | Not Dead Yet | 10 |
| Chuba Hubbard RB | CAR | The Dominators | 9.6 |
| Rico Dowdle RB | CAR | The Dominators | 9.6 |
| Michael Carter RB | ARI | W ( 10/8) | 9 |
| David Montgomery RB | DET | Mad Mudders | 9 |
| D’Andre Swift RB | CHI | Big Dog Sports | 8.8 |
| Rhamondre Stevenson RB | NE | Big Dog Sports | 8.4 |
| Tony Pollard RB | TEN | Here Goes Nothing | 8.4 |
| J.K. Dobbins RB | DEN | Team Up Honor | 8 |
| Alvin Kamara RB | NO | Lady Cougars | 7.8 |
| Cam Skattebo RB | NYG | Sack Attack | 7.8 |
| Bucky Irving RB | TB | Here Goes Nothing | 7.4 |
| Isiah Pacheco RB | KC | W ( 10/8) | 7.4 |
| Rachaad White RB | TB | Da Yoopers | 7 |
