| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Josh Allen QB | BUF | TB | 317 | 3 | 2 | 40 | 3 | 0 | 0 | 11 | 63 |
| Josh Allen QB | BUF | CIN | 251 | 3 | 0 | 78 | 1 | 0 | 0 | 14 | 51 |
| Josh Allen QB | BUF | BAL | 394 | 2 | 0 | 30 | 2 | 0 | 0 | 1 | 48 |
| Derrick Henry RB | BAL | @GB | 0 | 0 | 0 | 216 | 4 | 0 | 0 | 17 | 48 |
| James Cook RB | BUF | @CAR | 0 | 0 | 0 | 216 | 2 | 0 | 0 | 8 | 42 |
| Justin Fields QB | NYJ | @MIA | 226 | 1 | 0 | 81 | 1 | 0 | 0 | 4 | 40 |
| Derrick Henry RB | BAL | @BUF | 0 | 0 | 0 | 169 | 2 | 13 | 0 | 1 | 38 |
| Josh Allen QB | BUF | NO | 209 | 2 | 1 | 45 | 1 | 0 | 0 | 4 | 37 |
| Josh Allen QB | BUF | MIA | 213 | 3 | 0 | 25 | 0 | 0 | 0 | 3 | 34 |
| Justin Fields QB | NYJ | PIT | 218 | 1 | 0 | 48 | 2 | 0 | 0 | 1 | 33 |
| Josh Allen QB | BUF | @NE | 193 | 3 | 0 | 48 | 0 | 0 | 0 | 15 | 32 |
| Josh Allen QB | BUF | KC | 273 | 1 | 0 | 19 | 2 | 0 | 0 | 9 | 32 |
| Tee Higgins WR | CIN | CHI | 0 | 0 | 0 | 0 | 0 | 121 | 2 | 9 | 31 |
| James Cook RB | BUF | @NYJ | 0 | 0 | 0 | 132 | 2 | 3 | 0 | 2 | 31 |
| Josh Allen QB | BUF | @MIA | 306 | 2 | 1 | 31 | 0 | 0 | 0 | 10 | 31 |
| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Bye Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Brian Thomas Jr. WR | JAC | TEN | 0 | 0 | 0 | 21 | 1 | 658 | 2 | 8 | 80 |
| David Montgomery RB | DET | @CHI | 3 | 1 | 0 | 674 | 8 | 179 | 0 | 8 | 136 |
| Derrick Henry RB | BAL | @PIT | 0 | 0 | 0 | 1469 | 16 | 150 | 0 | 7 | 267 |
| Hunter Henry TE | NE | MIA | 0 | 0 | 0 | 0 | 0 | 712 | 7 | 14 | 116 |
| James Cook RB | BUF | NYJ | 0 | 0 | 0 | 1606 | 12 | 291 | 2 | 7 | 293 |
| Jayden Higgins WR | HOU | IND | 0 | 0 | 0 | 0 | 0 | 502 | 5 | 6 | 88 |
| Josh Allen QB | BUF | NYJ | 3668 | 25 | 10 | 579 | 14 | 0 | 0 | 7 | 473 |
| Kareem Hunt RB | KC | @LV | 0 | 0 | 0 | 597 | 8 | 122 | 1 | 10 | 114 |
| Oronde Gadsden II TE | LAC | @DEN | 0 | 0 | 0 | 0 | 0 | 641 | 3 | 12 | 78 |
| Tee Higgins WR | CIN | CLE | 0 | 0 | 0 | 0 | 0 | 779 | 10 | 10 | 164 |
| Wan’Dale Robinson WR | NYG | DAL | 0 | 0 | 0 | 5 | 0 | 1014 | 4 | 14 | 130 |
| Xavier Worthy WR | KC | @LV | 0 | 0 | 0 | 87 | 0 | 532 | 1 | 10 | 60 |
| Zay Flowers WR | BAL | @PIT | 0 | 0 | 0 | 62 | 1 | 1073 | 3 | 7 | 138 |
