| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Ashton Jeanty RB | LV | @HOU | 0 | 0 | 0 | 128 | 1 | 60 | 1 | 16 | 42 |
| Ashton Jeanty RB | LV | CHI | 0 | 0 | 0 | 138 | 1 | 17 | 2 | 4 | 38 |
| Daniel Jones QB | IND | TEN | 272 | 3 | 0 | 3 | 0 | 0 | 0 | 8 | 37 |
| Jayden Daniels QB | WAS | CHI | 211 | 3 | 1 | 52 | 0 | 0 | 0 | 6 | 35 |
| Sam Darnold QB | SEA | @ATL | 249 | 3 | 1 | 23 | 0 | 0 | 0 | 14 | 33 |
| Michael Penix Jr. QB | ATL | TB | 298 | 1 | 0 | 21 | 1 | 0 | 0 | 1 | 31 |
| Christian McCaffrey RB | SF | ATL | 0 | 0 | 0 | 129 | 2 | 72 | 0 | 7 | 31 |
| Sam Darnold QB | SEA | @TEN | 244 | 2 | 0 | -1 | 0 | 0 | 0 | 12 | 30 |
| Christian McCaffrey RB | SF | @ARI | 0 | 0 | 0 | 81 | 2 | 40 | 1 | 11 | 30 |
| Christian Watson WR | GB | CHI | 0 | 0 | 0 | 0 | 0 | 89 | 2 | 14 | 29 |
| Christian McCaffrey RB | SF | @NYG | 0 | 0 | 0 | 106 | 1 | 67 | 1 | 9 | 28 |
| RJ Harvey RB | DEN | DAL | 0 | 0 | 0 | 46 | 2 | 5 | 1 | 8 | 28 |
| Jayden Daniels QB | WAS | @GB | 200 | 2 | 0 | 17 | 0 | 0 | 0 | 2 | 28 |
| Omarion Hampton RB | LAC | @NYG | 0 | 0 | 0 | 128 | 1 | 37 | 0 | 4 | 27 |
| Daniel Jones QB | IND | HOU | 201 | 2 | 0 | 1 | 0 | 0 | 0 | 13 | 26 |
| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Bye Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Ashton Jeanty RB | LV | KC | 0 | 0 | 0 | 888 | 5 | 339 | 5 | 8 | 192 |
| Christian McCaffrey RB | SF | SEA | 0 | 0 | 0 | 1179 | 10 | 890 | 7 | 14 | 298 |
| Christian Watson WR | GB | @MIN | 0 | 0 | 0 | 3 | 0 | 611 | 6 | 5 | 112 |
| Dallas Goedert TE | PHI | WAS | 0 | 0 | 0 | 0 | 0 | 591 | 11 | 9 | 127 |
| Daniel Jones QB | IND | @HOU | 3101 | 19 | 8 | 164 | 5 | 0 | 0 | 11 | 286 |
| DK Metcalf WR | PIT | BAL | 0 | 0 | 0 | 12 | 1 | 850 | 6 | 5 | 137 |
| Emeka Egbuka WR | TB | CAR | 0 | 0 | 0 | 9 | 0 | 930 | 6 | 9 | 145 |
| Jameson Williams WR | DET | @CHI | 0 | 0 | 0 | 12 | 0 | 1043 | 7 | 8 | 166 |
| Jayden Daniels QB | WAS | @PHI | 1262 | 8 | 3 | 278 | 2 | 0 | 0 | 12 | 140 |
| Jordan Addison WR | MIN | GB | 0 | 0 | 0 | 81 | 1 | 602 | 3 | 6 | 98 |
| Omarion Hampton RB | LAC | @DEN | 0 | 0 | 0 | 545 | 4 | 192 | 1 | 12 | 102 |
| RJ Harvey RB | DEN | LAC | 0 | 0 | 0 | 512 | 7 | 351 | 5 | 12 | 162 |
| Sam Darnold QB | SEA | @SF | 3850 | 25 | 14 | 86 | 0 | 0 | 0 | 8 | 341 |
| Tyler Warren TE | IND | @HOU | 0 | 0 | 0 | 8 | 1 | 791 | 4 | 11 | 107 |
