| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Brock Purdy QB | SF | CHI | 303 | 3 | 1 | 28 | 2 | 0 | 0 | 17 | 48 |
| Brock Purdy QB | SF | @IND | 295 | 5 | 1 | 11 | 0 | 0 | 0 | 16 | 46 |
| Bo Nix QB | DEN | GB | 302 | 4 | 0 | 10 | 0 | 0 | 0 | 15 | 46 |
| Bo Nix QB | DEN | NYG | 279 | 2 | 0 | 48 | 2 | 0 | 0 | 7 | 44 |
| De’Von Achane RB | MIA | BUF | 0 | 0 | 0 | 174 | 2 | 51 | 0 | 10 | 43 |
| TreVeyon Henderson RB | NE | BUF | 0 | 0 | 0 | 148 | 2 | 13 | 0 | 15 | 39 |
| TreVeyon Henderson RB | NE | @TB | 0 | 0 | 0 | 147 | 2 | 3 | 0 | 10 | 38 |
| Bo Nix QB | DEN | DAL | 247 | 4 | 1 | -1 | 0 | 0 | 0 | 8 | 37 |
| Travis Etienne RB | JAC | NYJ | 0 | 0 | 0 | 32 | 0 | 73 | 3 | 15 | 37 |
| Brock Purdy QB | SF | TEN | 295 | 3 | 0 | 44 | 0 | 0 | 0 | 15 | 36 |
| Bo Nix QB | DEN | CIN | 326 | 2 | 1 | 7 | 1 | 0 | 0 | 4 | 35 |
| De’Von Achane RB | MIA | LAC | 0 | 0 | 0 | 128 | 2 | 22 | 0 | 6 | 32 |
| Amon-Ra St. Brown WR | DET | @LAR | 0 | 0 | 0 | 0 | 0 | 164 | 2 | 15 | 31 |
| Bo Nix QB | DEN | @IND | 206 | 3 | 1 | 20 | 0 | 0 | 0 | 2 | 29 |
| Amon-Ra St. Brown WR | DET | CHI | 0 | 0 | 0 | 7 | 0 | 115 | 3 | 2 | 29 |
| Player | Opponent | Pass Yds | PassTDs | INT | RushYds | RushTDs | RecYards | RecTDs | Bye Week | Points |
|---|---|---|---|---|---|---|---|---|---|---|
| Amon-Ra St. Brown WR | DET | @CHI | 0 | 0 | 0 | 9 | 0 | 1262 | 11 | 8 | 197 |
| Bo Nix QB | DEN | LAC | 3790 | 25 | 11 | 307 | 5 | 0 | 0 | 12 | 386 |
| Brock Purdy QB | SF | SEA | 2040 | 20 | 9 | 126 | 3 | 0 | 0 | 14 | 233 |
| Chris Godwin WR | TB | CAR | 0 | 0 | 0 | 0 | 0 | 352 | 2 | 9 | 44 |
| De’Von Achane RB | MIA | @NE | 0 | 0 | 0 | 1350 | 8 | 488 | 4 | 12 | 279 |
| DJ Moore WR | CHI | DET | 2 | 1 | 0 | 79 | 1 | 671 | 6 | 5 | 127 |
| Jakobi Meyers WR | JAC | TEN | 0 | 0 | 0 | 13 | 0 | 791 | 3 | 8 | 97 |
| Justin Jefferson WR | MIN | GB | 0 | 0 | 0 | 4 | 0 | 947 | 2 | 6 | 106 |
| Khalil Shakir WR | BUF | NYJ | 0 | 0 | 0 | 5 | 0 | 719 | 4 | 7 | 107 |
| Rachaad White RB | TB | CAR | 0 | 0 | 0 | 549 | 4 | 200 | 0 | 9 | 86 |
| Travis Etienne RB | JAC | TEN | 0 | 0 | 0 | 1075 | 7 | 286 | 6 | 8 | 233 |
| TreVeyon Henderson RB | NE | MIA | 0 | 0 | 0 | 858 | 7 | 221 | 1 | 14 | 166 |
| Trey McBride TE | ARI | @LAR | 0 | 0 | 0 | 0 | 0 | 1174 | 11 | 8 | 200 |
